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Download link : of radioisotope (11)C-choline PET/CT and 18F-fluorodeoxyglucose PET/CT in diffuse large B-cell lymphoma.
The purpose of this study was to evaluate the diagnostic performance of (11)C-choline positron emission tomography/computed tomography (PET/CT) and (18)F-fluorodeoxyglucose (FDG) PET/CT in detecting active diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed the PET/CT imaging studies of 50 patients with histopathologically confirmed DLBCL. (11)C-choline PET/CT and (18)F-FDG PET/CT were performed in all patients, and the results were compared with clinical follow-up and histopathology. An equal number of women and men were included in the study (median age, 51 years). Of the 50 patients, 34 (68%) had involved lymph nodes, 23 (46%) had extranodal lesions, and 8 (16%) had both. Of the 50 patients, 29 had involved (59%) and 21 had uninvolved lymph nodes on histopathology. Among the involved lymph nodes, 16 (55%) had high uptake on (11)C-choline PET/CT and 21 (72%) had high uptake on (18)F-FDG PET/CT. Of the 29 patients with involved lymph nodes, (11)C-choline PET/CT showed diffuse or focal uptake in 22 (76%) and (18)F-FDG PET/CT showed diffuse or focal uptake in 26 (90%). Among the 21 uninvolved lymph nodes, (11)C-choline PET/CT showed diffuse or focal uptake in 5 (24%) and (18)F-FDG PET/CT showed diffuse or focal uptake in 4 (19%). (11)C-choline PET/CT and (18)F-FDG PET/CT have similar sensitivity in identifying patients with active lymph node involvement or

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